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Patrick Dempsey is an assassin with Alzheimer’s in trailer for Memory of a Killer

December 31, 2025 by Amie Cranswick

Fox has shared a trailer for the upcoming thriller series Memory of a Killer.

Based on the 2003 Belgian film De Zaak Alzheimer, the series stars Patrick Dempsey as Angelo Ledda, a man who sees the wall he’s built up between his two separate lives as sleepy upstate salesman and family man, and the perilous job of a NYC hitman, threaten to crumble when he is diagnosed with early onset Alzheimer’s. Check out the trailer below…

Losing one’s memory is a devastating hammer blow for anyone, but for Angelo Ledda, the stakes couldn’t be higher. His hit man job would be perilous enough, but there’s an added pressure: Angelo lives two totally separate lives — fearsome NYC hitman, and sleepy upstate Cooperstown photocopier salesman and father. Having built and maintained a brick wall between his two worlds, Angelo has seamlessly juggled and compartmentalized for years. But now that’s all about to change, because Alzheimer’s is a foe he can’t outrun, and he knows too well how this ends, as his older brother is already lost to the condition.

Angelo is exceptionally resourceful and talented, the best of the best. But he’s about to be tested like never before — and now every minute counts. This is only made more difficult when he discovers that his wife’s recent death may not have been an accident. So, when someone comes after his daughter — who is pregnant — it’s clear the wall between his lives has been breached. Angelo must stop whoever’s coming for his family by searching his past hits for clues, and the list is very long. Now Angelo must hunt down his mortal enemy while continuing to carry out hits without giving away his diagnosis and still making it home in time to cook dinner for his daughter. Memory of a Killer is a redemptive story about a man who is losing his memory but gaining a conscience. Because Angelo knows he must stop history from repeating itself and save his family — before he forgets the past.

Memory of a Killer premieres on Fox on January 25th.

 

Filed Under: Amie Cranswick, News, Television, Trailers Tagged With: Memory of a Killer, Patrick Dempsey

About Amie Cranswick

Amie Cranswick is the Executive Editor of Flickering Myth, overseeing editorial coverage across film, television and pop culture.

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